Climate change is one of the most important global environmental challenges facing humanity with implications for food production, natural ecosystems, freshwater supply, health, etc. According to the latest scientific assessment, the earth’s climate system has demonstrably changed on both global and regional scales since the pre-industrial era. Further evidence shows that most of the warming (0.1°C per decade) observed over the last 50 years, is attributable to human activities. Climate change is affecting the vegetation and leading to their habitat fragmentation, phenological variations, spread of invasive species, increased number of forest fires, pest attacks and extinctions. This review article discusses on the impacts of climate change on plants and how plants could be used as mitigators of climate change. Trees can prevent climate change by sequestering carbon dioxide, a very potent greenhouse gas and storing it in their biomass, in roots, as phytoliths, bioenergy crops and by afforestation, reforestation and agroforestry practices.