Volume 15 2021 Issue 8
Keywords: Burn; Regeneration; Fibrosis
Introduction: Hypertrophic scars represent the most common complication resulting from burn injury, and their pathological hallmark is excessive deposition of fibroblast-derived extracellular matrix proteins. Calpain, a calcium-dependent endopeptidase, mediates fibroblast activation and collagen syn...
Keywords: Ion channel, Wound, Scar, Pathogenesis
A pathophysiological hallmark of hypertrophic scarring is the overactivation of fibroblasts, which results in their proliferation along with overproduction of the extracellular matrix. The Gardos channel (KCa3.1) is reported to mediate fibroblast activation in multiple clinical conditions; however, ...
Keywords: Regeneration; Fibrosis; Pathophysiology
Abstract: Hyperproliferation of fibroblasts and excessive extracellular matrix (ECM) deposition are pathological hallmarks of hypertrophic scars, the most common complication of burn injury. Calpains are Ca2+-dependent proteases and associated with fibroblast proliferation and ECM synthesis, resulti...
Keywords: Department of Restorative Dentistry, Medical University of Sofia, Bulgaria
In the past three decades, advancements in dental materials have introduced more esthetic options for the restoration of posterior teeth. This study investigates the application of indirect biomimetic restorations, such as inlays and onlays, using ceramic materials to enhance the esthetic and functi...
Keywords: Indian Institute of Technology Kharagpur, Department of Computer Science, India
Language Identification has gained significant importance in recent years, both in research and commercial marketplaces, demanding an improvement in the ability of machines to distinguish between languages. Although methods like Gaussian Mixture Models, Hidden Markov Models, and Neural Networks are ...
Keywords: Institute of Pharmaceutical Sciences, Tehran University of Medical Sciences, Iran
Photodynamic therapy (PDT) is an innovative medical treatment that involves the use of a photosensitizing drug activated by visible light to selectively destroy cancer cells. Over the past two decades, PDT has evolved significantly in both laboratory research and clinical applications. Although stil...
Keywords: H.N.B. Garhwal University, Department of Botany, India
In this study, we investigated the rooting ability and growth performance of Tecoma stans using various shoot positions and cutting types, including softwood, hardwood, leafy, and non-leafy shoot cuttings. The cuttings were sourced from mature plants located at the Chauras Campus of H.N.B. Garhwal U...
Keywords: Institute of Agricultural Sciences, Beijing, China
A novel, environmentally friendly seed coating agent for maize is formulated from natural polysaccharide polymers extracted from pollution-free aquatic sources in the deep sea, complemented by additional additives. Laboratory and field tests demonstrate that this seed coating agent achieves an antib...