Vol. 19, Issue 10
2025
ID: 7ZyUd
Markus J. Schneider, Li Xiaolong, Fatima Al-Zahra
Understanding the mechanisms of protein folding remains a central challenge in biophysics. This study focuses on the kinetic pathways and thermodynamic stability in the folding of small globular proteins. We aimed to elucidate the interplay between f...
Vol. 19, Issue 10
2025
ID: ZuSvs
Lu Wei-Ming, Dieter H. Schneider, Priya Venkataraman
Gene therapy has emerged as a promising approach for the treatment of monogenic disorders, leveraging advances in genome editing technologies. This study aims to evaluate the efficacy and safety of CRISPR-Cas9 mediated gene therapy in correcting gene...
Vol. 17, Issue 6
2023
ID: 4RmZw
Bei Liu, Bin Zhang, Lixia Yang, Ruiwei Guo
Objective: RNA interference (RNAi) is a widely used mechanism to knock down target gene expression. Successful application of RNAi requires efficient delivery of siRNA into cells. This study demonstrates an efficient and specific knockdown of stim1, ...