Vol. 20, Issue 3
Section 1
ID: nZSN5
Anja M. Bauer, Yu-Ting Huang, Arjun R. Mehta
Keywords: Anja M. Bauer, Department of Biophysics, Ludwig Maximilian University of Munich, Germany; Yu-Ting Huang, Institute of Molecular Biology, Academia Sinica, Taiwan; Arjun R. Mehta, Department of Biotechnology, Indian Institute of Technology Delhi, India
Understanding the complex process of protein folding is crucial for deciphering cellular functions and developing therapeutic strategies for protein-misfolding diseases. This study investigates the biophysical properties influencing the folding pathways of multi-domain proteins. Utilizing a combinat...
Vol. 20, Issue 3
Section 1
ID: 454cE
Svenja Müller, Hiroshi Nakagawa, Faiza El-Hashemi
Keywords: Department of Ophthalmology, University of Freiburg, Germany; Department of Genetic Medicine, University of Tokyo, Japan; Department of Biochemistry, American University of Beirut, Lebanon
Hereditary retinal degenerations represent a leading cause of blindness with genetic defects that affect millions globally. This study aimed to explore novel gene therapy strategies to address these debilitating conditions. We employed adeno-associated virus vectors to deliver therapeutic genes into...
Vol. 20, Issue 3
Section 1
ID: FXbtr
Anja R. Müller, Hiroshi Saito, Fatima El-Raziq
Keywords: Anja R. Müller: Department of Neurobiology, University of Freiburg, Germany; Hiroshi Saito: Department of Physiology, Kyoto University, Japan; Fatima El-Raziq: Neuroscience Research Center, American University of Beirut, Lebanon
Synaptic plasticity, a fundamental mechanism underlying learning and memory, is modulated by a variety of cellular and molecular processes. Recent studies suggest that astrocytes, through calcium signaling, play a crucial role in regulating synaptic plasticity. This study aims to elucidate the role ...
Vol. 20, Issue 3
Section 1
ID: pDn9S
Jasper L. van der Meer, Mei-Ling Huang, Ahmed Al-Hashimi
Keywords: Department of Computational Biology, Leiden University, Netherlands; Department of Bioinformatics, Tsinghua University, China; Department of Systems Biology, King Saud University, Saudi Arabia
The rapid advancement in computational biology has opened new avenues for exploring protein-protein interaction (PPI) networks, particularly in cancer research. This study aims to elucidate the complexity of PPIs in oncogenesis and propose potential therapeutic targets. Using an integrative bioinfor...
Vol. 20, Issue 3
Section 1
ID: WxAZc
Anna-Maria Heine, Wu Jian-Hong, Nandini A. Patel
Keywords: Immunology Department, University of Heidelberg, Germany; Department of Biotechnology, Tsinghua University, China; Department of Biochemistry, Indian Institute of Science, India
Antibody engineering has significantly advanced the field of immunotherapy, providing novel approaches to enhance therapeutic efficacy against a variety of diseases. The objective of this study was to develop and optimize engineering techniques for antibodies with improved affinity and specificity. ...
Vol. 20, Issue 3
Section 1
ID: QmrBK
Ingrid J. Müller, Chen Liang-Zhi, Thandeka Ndlovu
Keywords: Department of Biochemistry, University of Heidelberg, Germany; Department of Biochemistry, Tsinghua University, China; Department of Molecular Biology, University of Cape Town, South Africa
Understanding the precise mechanisms by which enzymes achieve catalysis is crucial for advancements in biochemistry and drug design. This study focuses on the allosteric regulation of catalytic triads in serine proteases, enzymes that play a vital role in numerous biological processes, including dig...
Vol. 20, Issue 3
Section 1
ID: ntrgr
Emma B. Johansson, Ramesh Nair, Farah El-Moussa
Keywords: Department of Microbiology, Uppsala University, Sweden; Department of Biotechnology, Indian Institute of Technology Delhi, India; Department of Molecular Biology, American University of Beirut, Lebanon
Pseudomonas aeruginosa is a prominent opportunistic pathogen responsible for severe infections, particularly in immunocompromised patients. The bacterium's ability to evade host immune responses is a significant factor in its pathogenicity. This study aims to delineate the cellular mechanisms employ...
Vol. 20, Issue 3
Section 1
ID: PGmhD
Jürgen W. Müller, Hiroshi Nakamura, Aditi Mehta
Keywords: 1. Department of Molecular Biology, University of Heidelberg, Germany; 2. Department of Genetics, Kyoto University, Japan; 3. Department of Biotechnology, Indian Institute of Technology Delhi, India
Understanding the regulatory mechanisms of gene expression is pivotal in elucidating cellular responses to environmental stressors. This study focuses on the heat shock protein (HSP) gene expression in Drosophila melanogaster, a model organism in genetic research. Our objective was to map the transc...